Serum amyloid A – A prime candidate for identification of neonatal sepsis

Neonatal sepsis is common, lethal, and hard to diagnose. In combination with clinical findings blood culture, biomarkers are crucial make the correct A Swedish national inquiry indicated that neonatologists were not quite satisfied available biomarkers. We assessed kinetics of 15 simultaneously: ferritin, fibrinogen, granulocyte colony-stimulating factor (G-CSF), interferon (IFN)-γ, interleukin (IL)-1β, −6, −8, −10, macrophage inflammatory protein (MIP)-1β, procalcitonin, resistin, serum amyloid (SAA), tumor necrosis (TNF)-α, tissue plasminogen activator-3 visfatin. The goal was observe how quickly they rise in response infection, for long remain elevated. From a neonatal intensive care unit, newborns ≥28 weeks gestational age recruited. Sixty-eight recruited study group (SG), fifty-one control (CG). subjects divided into three subgroups depending on findings: confirmed (CSG), suspected (SSG) no sepsis. CSG SSG also merged an entire (ESG) sub-analysis. Blood samples collected at time-points; 0 h, 12–24 h 48–72 order mimic “clinical setting”. At visfatin elevated compared CG; G-CSF, IFN-γ, IL-1β, −8 − 10 ESG CG, whereas IL-6 SAA all groups CG. IL-8 fibrinogen IFN-γ IL-1β function time-formula introduced as tool theoretical prediction biomarker levels any time-point. conclude has most favorable regarding diagnosing sepsis, studied. It readily methodologically, making it prime candidate use.